HK Neopharm Limited yog ib qho ntawm feem txhim khu kev qha manufacturers thiab lwm tus neeg ntawm eplontersen api nyob rau hauv Suav teb, featured los ntawm cov khoom zoo thiab tus nqi zoo. Thov so assured mus yuav eplontersen api hauv Tshuag ntawm no thiab tau txais cov lus hais los ntawm peb lub hoobkas. Customized xaj yog txais tos.
Eplontersen API (CAS 1637600-16-}8) yog ib lub cim tshiab ntawm daim siab-targeted antisense oligonucleotide raw khoom uas xaiv inhibits transthyretin (TTR) synthesis. Nws muab kev kho tshiab rau kev kho mob ATTR amyloidotic polyneuropathy nrog kev ua haujlwm siab thiab kev nyab xeeb zoo. Los ntawm kev txo TTR ntau ntau thiab tiv thaiv amyloid fibril deposition, nws muaj txiaj ntsig ncua kev kis kab mob thiab txhim kho kev ua haujlwm ntawm lub paj hlwb, ua cov tshuaj tseem ceeb rau kev kho mob ATTR amyloidosis.
Technical Specifications
|
Khoom npe |
Eplontersen API |
|
Synonyms |
Eplontersen Powder, Eplontersen Raw Khoom |
|
Yam ntxwv |
Ib tug tawm -dawb mus rau lub teeb daj hmoov hmoov |
|
CAS Nr |
1637600-16-8 |
|
Assay |
Ntau dua los yog sib npaug rau 99.0% (HPLC, Raws li COA) |
|
Formula |
GalNAc3-conjugated 20-mer ASO |
|
Pob |
Pob txheej txheem |
|
Cia |
Khaws ntawm -20℃rau 3 xyoos lossis 4℃rau 2 xyoos, nruj nreem kaw, qhuav, tiv thaiv lub teeb; cia nyob rau hauv nitrogen yog pom zoo. Kev daws teeb meem: ruaj khov rau 6 lub hlis ntawm -80℃lossis 1 lub hlis ntawm -20 degree; zam rov qab khov-thaw cycles. |
|
Qauv |
|
Eplontersen Powder yog ib lub hom phiaj antisense oligonucleotide API tsom rau cov kab mob transthyretin amyloidosis, nrog tus nqi tseem ceeb hauv kev kho kab mob tsawg. Nws silences pathogenic gene qhia los thaiv qhov txawv txav ntawm cov protein tsim, xa cov khoom siv txhim khu kev qha rau kev siv tshuaj kho mob.
Khoom nta
Eplontersen API (CAS 1637600-16-8) nta GalNAc₃ conjugation rau qhov tseeb hepatocyte targeting, txhim kho kev xa khoom, txo qis kev raug mob, thiab txhim kho kev nyab xeeb thiab kev zam.
Raws li 20-mer antisense oligonucleotide, Eplontersen Raw Khoom tshwj xeeb degrades TTR mRNA los inhibit pathogenic protein synthesis nrog tsawg cuam tshuam rau ib txwm physiological pathways.
Nrog HPLC- kuaj purity Ntau dua lossis sib npaug rau 99.0%, cov khoom ua tau raws li qib API cov qauv tshuaj. Nws yog cov hmoov dawb lyophilized nrog kev ruaj ntseg zoo ntawm -20 degree, haum rau kev tsim kho thiab kev tsim khoom loj.
Full -Cycle Quality Control & Consistent Quality
Qhov Chaw Tswj & Ua Raws Li Raw Materials
Eplontersen API yog tag nrho traceable los ntawm pib cov ntaub ntawv mus rau intermediates, tag nrho cov ua raws li pharmacopoeial yuav tsum tau kom batch sib xws thiab txhim khu kev qha zoo.
Txheej txheem tswj & Precise Management
Tag nrho cov txheej txheem tsim khoom siv tiag tiag- lub sijhawm saib xyuas thiab kev tswj hwm nruj kom tswj tau qhov kev tsim khoom ruaj khov, txo cov impurities, thiab lav cov khoom purity thiab kev ua haujlwm.
Cov khoom tiav Kev Xeem & Cov qauv nruj
Cov khoom tiav tau lees paub los ntawm HPLC, LC-MS thiab lwm txoj hauv kev. Purity Ntau dua lossis sib npaug li 99.0%, nrog rau txhua qhov ntsuas tau ntsib ICH thiab kws tshuaj - qib API specifications.
Nruam Optimization & Kev ruaj ntseg ruaj khov
Ib daim ntawv qhia tag nrho -lifecycle zoo traceability system yog siv nrog cov txheej txheem kev txheeb xyuas cov txheej txheem tsis tu ncua thiab kev tshawb fawb kev ruaj ntseg kom ntseeg tau tias qhov zoo ib yam nyob rau hauv ntev - lub sij hawm cia thiab khoom loj.
Daim ntawv thov Scenario
Nrog rau kev ua haujlwm siab thiab txhim khu kev qha, Eplontersen API tau siv dav hauv cov tshuaj tshiab R & D, kev tsim kho thiab kev tshawb fawb txog kev kho mob tsawg.
Nws yog tsuas yog siv rau hauv kev txhim kho thiab tsim cov tshuaj rau kev hloov pauv ntawm transthyretin amyloidosis, txhawb kev kho cov qauv tsim kho thiab kho cov khoom siv.
Nws ua haujlwm rau cov tuam txhab tshuaj thoob ntiaj teb rau kev sau npe tshuaj, kev sim tshuaj thiab kev tsim khoom lag luam, muab kev txhawb nqa ruaj khov rau daim siab - cov tshuaj oligonucleotide cov tshuaj.
Nws kuj txhawb kev tshawb fawb qib siab hauv kev kho mob tsis tshua muaj kab mob, muab cov khoom siv siab- zoo rau kev tshawb fawb txog kev siv tshuab thiab kev kho tshiab.
Tau tshaj thoob ntiaj teb cov chaw muag tshuaj, nws muaj rau R&D cov koom haum, chaw tsim khoom thiab CDMOs rau R&D, pilot thiab loj - teev ntau lawm.
Ntim thiab thauj
Txhawm rau khaws cov khoom zoo thiab kev ua haujlwm ntawm Eplontersen API, peb siv tshuaj - cov qauv qib rau kev ntim khoom, kev thauj mus los thiab tag nrho - txheej txheem traceability kom ntseeg tau tias kev xa khoom zoo.
Cov khoom no tau ntim rau hauv cov chaw muag tshuaj - qib ntim ntim nrog lub teeb thiab tiv thaiv noo noo thiab tsis muaj roj pam. Ntau qhov tshwj xeeb muaj, thiab kev ntim khoom Eplontersen API tau txais kev txhawb nqa.
Kev thauj mus los yog ua los ntawm qhov qis-kub txias txias nrog cov thawv insulated thiab cov dej khov qhuav kom tsis txhob muaj qhov kub thiab txias dua -thaw cycles.
Tag nrho cov pob khoom tau sau meej meej nrog cov lej taug qab, ua raws cov kev cai thauj khoom thoob ntiaj teb thiab ua kom muaj kev ntseeg siab hla - xa tuaj rau ciam teb.
Peb Qhov Zoo
Core Technology
Nrog kev nplua nuj nyob hauv oligonucleotide APIs, peb muaj cov txheej txheem hluavtaws ua kom muaj kev ruaj khov ntawm Eplontersen API nrog zoo ib yam.
Kev Tswj Xyuas Zoo
Peb siv tag nrho - txheej txheem kev tswj kom zoo. Txhua batch raug soj ntsuam tag nrho, nrog purity thiab impurity tswj tshaj cov qauv kev lag luam.
Supply & Service
Peb muab cov khoom siv tau yooj yim los ntawm cov qauv R & D me me rau kev txiav txim loj loj, nrog kev xa khoom sai los txhawb kev tsim tshuaj thiab kev sau npe.
Kev pab txhawb nqa
Peb pab pawg kws tshaj lij thiab kev tswj hwm muab cov ntaub ntawv tiav thiab kev txhawb nqa tus kheej los pab txhawb kev tsim kho qhov project.
FAQ
Raws li ib tug kws tshaj lij Tuam Tshoj Eplontersen API chaw tsim tshuaj paus, peb tsim Eplontersen API ua nyob rau hauv Suav teb raws li nruj thoob ntiaj teb zoo systems nrog tag nrho traceability. Raws li cov ntaub ntawv tseem ceeb rau ATTR amyloidosis therapy, Eplontersen Raw Material txhawb cov tshuaj R & D thiab kev lag luam ntau lawm hauv cov kab mob tsawg. Nrog cov khoom ruaj khov thiab cov kev pabcuam tshaj lij, peb koom tes nrog cov neeg koom tes thoob ntiaj teb los txhawb kev nce qib hauv kev kho kab mob tsawg.
Cim npe nrov: Tuam Tshoj eplontersen API manufacturers, lwm tus neeg, Hoobkas
