HK Neopharm Limited yog ib qho ntawm feem txhim khu kev qha manufacturers thiab lwm tus neeg ntawm zavegepant hydrochloride nyob rau hauv Suav teb, featured los ntawm cov khoom zoo thiab tus nqi zoo. Thov so assured mus yuav zavegepant hydrochloride hauv Tshuag ntawm no thiab tau txais cov lus hais los ntawm peb lub hoobkas. Customized xaj yog txais tos.
Zavegepant Hydrochloride (CAS 1414976-20-7) yog ib qho kev xaiv calcitonin gene-related peptide (CGRP) receptor antagonist (cov tshuaj muaj tshuaj nquag, API). Nws yog synthesized los ntawm 2,6-dimethylaniline thiab lwm yam raw cov ntaub ntawv los ntawm ntau cov txheej txheem uas muaj condensation, asymmetric hydrogenation, thiab chiral siv.
Raws li lub ntiaj teb thawj qhov ntswg tshuaj tsuag API rau kev kho mob migraine, nws tuaj yeem txo qhov mob taub hau sai sai thiab cov tsos mob tshwm sim. Lub hauv paus ntawm nws cov txheej txheem tsim khoom yog nyob rau hauv chiral tswj; cov khoom nthuav tawm kev ruaj ntseg zoo heev, thiab kev lag luam xav tau txuas ntxiv mus ntxiv.
Technical Specifications
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Khoom npe |
Zavegepant Hydrochloride |
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Synonyms |
Zavegepant HCl API, Zavegepant HCL |
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Yam ntxwv |
Dawb los yog tawm - hmoov dawb. |
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CAS Nr |
1414976-20-7 |
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Assay |
Ntau dua los yog sib npaug rau 99.0% (HPLC, Raws li COA) |
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Formula |
C36H47CIN8O3 |
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Pob |
Standard Ntim: 1kg / Aluminium Ntawv Nyiaj Hnab, 5kg / Aluminium Drum, 25kg / Fiber Drum (nrog ob lub hnab polyethylene) Kev ntim khoom: Muaj raws li qhov kev thov, nruj me ntsis kaw hauv qab roj inert kom tsis txhob ya raws thiab oxidation |
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Cia |
Luv-term / Routine storage: Txias ntawm 2–8 degree, kaw, qhuav, tiv thaiv lub teeb, nyob rau hauv inert gas tiv thaiv. Ntev -lub sij hawm / Cov Khoom Muag Khoom Muag: Txias ntawm −20 degree, ruaj khov rau 3 xyoos. Kev daws teeb meem: Khaws ntawm −80℃mus txog 1 xyoo lossis ntawm −20℃rau kwv yees li 1 lub hlis; zam rov qab khov -thaw cycles. |
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Qauv |
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Peb Zavegepant HCl hmoov yog tsim nrog Zavegepant HCl hmoov featuring meej tswj batch - mus rau -batch sib xws. Nrog superior zoo uniformity thiab batch controllability, nws yog zoo kawg nkaus haum rau tag nrho cov txheej txheem scenarios xws li nasal spray formulation txoj kev loj hlob, pharmacodynamic kev tshawb fawb, thiab kev kho mob - qib daim ntawv thov.
Khoom nta
Nrog nws qhov tshwj xeeb CGRP receptor antagonistic mechanism, CAS 1414976-20-7 precisely lub hom phiaj ntawm kev kho mob migraine, muab cov kev daws teeb meem zoo rau cov kev xav tau kho mob tsis zoo. Cov xwm txheej tshiab ntawm nws txoj kev xa tshuaj ntawm qhov ntswg tsis tsuas yog ua kom muaj kev pib sai dua thiab kev tswj hwm yooj yim dua, tab sis kuj qhib qhov sib tw sib tw toj roob hauv pes tsim kho, pab cov neeg siv khoom tsim cov khoom kho mob migraine nrog cov txiaj ntsig kho mob ntau dua.
Raws li cov kws tshaj lij Tuam Tshoj cov tuam ntxhab ntawm Zavegepant Hydrochloride (CAS 1414976-20-7), peb muab cov khoom lag luam nrog cov khoom siv hluav taws xob zoo, cov dej solubility tshwj xeeb thiab ruaj khov-state stability.Lawv tsis tsuas yog ua tiav cov kev cai nruj ntawm qhov ntswg tshuaj formulations rau kev sib cais, nqus thiab ruaj khov, tab sis kuj muab cov chav loj loj los yog kev loj hlob. Kev npaj.With siab purity thiab controllable impurities, peb cov khoom yuav txo tau qhov nyuaj ntawm formulation tshuaj ntsuam xyuas, txo formulation rework thiab stability txaus ntshai los ntawm raw cov ntaub ntawv teeb meem, thiab heev shorten lub formulation R & D voj voog.
Kev cia siab rau peb cov txheej txheem tsim khoom loj loj thiab ua raws li cov txheej txheem ruaj khov thiab rov ua dua, peb ua tiav qhov zoo sib xws hauv batch-to-batch zoo, zam kev hloov pauv zoo los ntawm kev tsis sib haum xeeb ntawm chav kuaj- cov ntaub ntawv teev thiab kev lag luam ntau lawm.Our ruaj khov muaj peev xwm thiab traceable ntau lawm system zoo txhawb cov neeg siv khoom 'tag nrho-cycle raw khoom xav tau los ntawm kev tshawb fawb thiab kev lag luam kev lag luam tawm thaum ntxov.
Peb muab cov ntaub ntawv tshawb fawb zoo thiab muaj txiaj ntsig zoo txhawb nqa peb Zavegepant HCL API (cov khoom siv tshuaj nquag), suav nrog cov khoom ntsuas tseem ceeb suav nrog kev soj ntsuam, cov tshuaj muaj feem xyuam, cov kuab tshuaj seem, cov ntsiab lus noo noo thiab cov khoom tsis huv. Nrog cov ntaub ntawv tsim nyog thiab cov ntaub ntawv ua tiav, cov ntaub ntawv no tuaj yeem txhawb nqa ncaj qha rau kev npaj cov tshuaj dossiers nrog rau cov ntaub ntawv sau npe hauv tsev thiab txawv teb chaws.Cov khoom yog tsim los ntawm nruj raws li GMP cov hauv paus ntsiab lus, thiab nws cov impurity tswj tau raws li cov kev cai ntawm ICH cov lus qhia thiab cov chaw muag tshuaj loj.
Full -Cycle Quality Control & Consistent Quality
Zoo yog qhov tseem ceeb ntawm kev sib tw ntawm Zavegepant HCL API. Peb tau tsim kom muaj tag nrho - txheej txheem tswj kev ua tau zoo los ntawm cov khoom siv raw mus rau cov khoom tiav tiav, txhawb kev siv tshuaj R&D thiab cov ntawv sau npe nrog kev ruaj khov thiab txhim khu kev qha.
Synthetic txheej txheem tswj
CAS 1414976-20-7 yog tsim los ntawm kev ua kom zoo tshaj plaws cov khoom siv hluavtaws nrog kaw-voj saib xyuas cov tshuaj tiv thaiv tsis zoo. Pub piv, cov tshuaj tiv thaiv kub ntau thiab lub sijhawm hloov pauv tau raug tswj hwm los tswj cov txheej txheem impurities thiab isomers ntawm cov theem tsim khoom, ua kom ruaj khov thiab tswj tau qhov nruab nrab zoo.
Refining thiab Purification
Zavegepant Hydrochloride tau dhau los ua ntau-theem recrystallization, precision pom, nqus kom qhuav thiab lwm yam kev ntxuav kom huv kom zoo tshem tawm cov khoom seem thiab cov kuab tshuaj. Nws daim ntawv siv lead ua thiab qhov loj me me yog tswj hwm nruj, kom ntseeg tau tias cov khoom purity thiab physicochemical zog ua raws li cov qauv tshuaj pharmacopoeial thiab ICH cov lus qhia.
Kev Ntsuam Xyuas thiab Tso Cai Tswj
Daim Ntawv Pov Thawj Ua tiav ntawm Kev Ntsuam Xyuas (COA) yog muab rau txhua pawg ntawm Zavegepant Hydrochloride (CAS 1414976-20-}7), suav nrog txhua qhov ntsuas suav nrog cov tshuaj muaj feem xyuam, tshuaj ntsuam xyuas, cov kuab tshuaj seem, noo noo, melting point thiab tsos. Cov ntaub ntawv ntsuam xyuas tau ua tiav tag nrho nrog kev ua haujlwm zoo ib yam li batch-to-batch, ua tau raws li cov qauv kev tswj xyuas nruj rau kev tshuaj R & D, kev tsim khoom tsim thiab kev sau npe.
Product Stability thiab Batch Consistency:Peb tau tsim ib lub sijhawm ntev - kev soj ntsuam kev ruaj ntseg thiab tiag - lub sij hawm batch sib piv mechanism. Kev tshawb fawb nrawm nrawm, ntev- xyuas lub sijhawm khaws cia, thiab kev tshawb fawb kev ruaj ntseg nyob rau hauv lub teeb, av noo thiab cua sov ua kom pom tseeb qhov kev ruaj ntseg zoo ntawm Zavegepant HCL nyob rau hauv niaj hnub cia thiab kev thauj mus los, zoo txo qis kev pheej hmoo ntawm degradation thiab ua kom tsis muaj kev hloov pauv tseem ceeb hauv cov khoom ntsuas thoob plaws hauv nws lub neej txee.
Daim ntawv thov Scenario
Cov ntawv thov tseem ceeb ntawm Zavegepant HCl tsom rau R & D, kev tsim khoom thiab kev tshawb fawb tshawb fawb txog kev kho mob migraine, nrog rau cov xwm txheej tshwj xeeb raws li hauv qab no:
Formulation Development:
Nws yog tsuas yog siv rau kev tshuaj ntsuam xyuas, txheej txheem optimization thiab kev sib raug zoo ntawm kev tshawb fawb ntawm cov ntaub ntawv tshiab xws li tshuaj tsuag qhov ntswg thiab qhov ncauj npaj. Nws tsom rau kev txhawb nqa kev tshawb nrhiav kev ruaj ntseg thiab bioavailability optimization ceev ceev- pib, npaj cov mucosal haum, thiab muab cov ntaub ntawv tseem ceeb rau kev txhim kho cov tshuaj kho mob migraine sib txawv nrog Customized Zavegepant HCl API.
Kev Sau Npe & Kev Tshawb Fawb Preclinical
Nws tuaj yeem siv rau hauv kev tshuaj ntsuam xyuas tshuaj thiab kev ua tau zoo, kev tshawb fawb tshuaj pharmacokinetic thiab kev ntsuas kev nyab xeeb, ua tau raws li qhov xav tau ntawm cov tuam txhab tshuaj rau qib siab - cov qauv siv tau zoo thiab kuaj APIs hauv IND cov ntaub ntawv thiab cov theem kev tshawb fawb soj ntsuam, ua kom tiav cov ntaub ntawv tshawb fawb thiab kev sau npe ua tiav.
Kev tsim khoom lag luam:
Cia siab rau qhov ruaj khov loj- teev muaj peev xwm ntau lawm, peb muab cov chaw muag tshuaj nrog Zavegepant Hydrochloride ua hauv Suav teb uas ua tau raws li cov qauv tshuaj. Peb txhawb nqa kev tsav tsheb- ntsuas qhov ntsuas thiab kev lag luam loj- nplai ntau lawm, xyuas kom muaj kev ruaj khov thiab ruaj khov ntawm ntau cov khoom siv, thiab hloov mus rau lub sijhawm ntev - kev tsim khoom thiab kev lag luam xav tau ntawm cov tshuaj lag luam.
Kev Tshawb Fawb Txog Kev Tshawb Fawb
Nws yog muab rau cov koom haum tshawb fawb txog kev txiav- cov kev tshawb fawb txog kev kawm ntawm CGRP receptor mechanisms thiab cov tswv yim kho mob migraine, txhawb kev nce qib hauv kev lag luam.
Ntim thiab thauj
Kev txiav txim siab tias Zavegepant HCl API yog qhov ua rau muaj kev hloov pauv hauv qhov tshwm sim ntawm qhov kub thiab txias, av noo thiab lub teeb, peb tau tsim kho tag nrho - txheej txheem ntim thiab kev tiv thaiv kev thauj mus los los ua kom cov khoom lag luam ruaj khov los ntawm kev tsim khoom mus rau kev xa khoom.
Precise Temperature & Humidity Control thiab Traceability
Raws li kev saib xyuas ntawm hygroscopic thiab qhov kub thiab txias-rhiab qhov xwm txheej ntawm Zavegepant Hydrochloride, qhov tsis tu ncua -kub txias- kev thauj mus los yog saws thoob plaws hauv tag nrho cov txheej txheem, nruab nrog lub sijhawm tiag tiag - ntsuas kub thiab av noo ntsuas cov cuab yeej nrog tsis siv neeg tshaj- tswb ntsuas kub. Tag nrho - cov ntaub ntawv txheej txheem raug kaw thiab ib daim ntawv qhia txog kev tswj qhov kub thiab txias tau muab nrog cov khoom xa tuaj. Kev khaws cia thiab kev thauj mus los kub yog nruj me ntsis tswj ntawm 2-8℃los tiv thaiv kev hloov pauv ntawm qhov kub thiab av noo los ntawm kev cuam tshuam cov khoom purity thiab stability.
Kev tiv thaiv lub teeb thiab txhim kho ntim
Xav txog cov photosensitivity ntawm cov khoom, txheej ntim siv ob - txheej lub teeb - pov thawj aluminium foil hnab ntxiv rau lub teeb - pov thawj kis, nrog zaub mov- qib desiccants sab hauv kom muab ob npaug ntawm kev sib cais ntawm lub teeb thiab noo noo. Cov ntawv ceeb toom meej meej xws li "Tiv thaiv los ntawm Lub Teeb, Moisture, Txias Cia" yog cim rau ntawm sab nrauv kom tsis txhob muaj cov khoom degradation los ntawm lub teeb raug lossis noo noo nqus thaum thauj thiab khaws cia, yog li khaws cia zoo.
Standardized Storage thiab Shelf-Life Management
Raws li Tuam Tshoj Zavegepant Hydrochloride Hoobkas, peb qhov chaw cia khoom nruj me ntsis ua raws li GMP cov cai, nruab nrog cov chaw khaws khoom kub thiab av noo tas li, cais cov chaw khaws cia thiab cov neeg ua haujlwm siab rau kev tswj hwm, ua raws li thawj -hauv thawj- tawm hauv paus ntsiab lus. Peb ua kev soj ntsuam kev ruaj ntseg tsis tu ncua ntawm cov khoom muag khoom thiab tsim kom muaj lub txee- lub neej ceeb toom mechanism kom ceeb toom cov neeg siv khoom ntawm lub voj voog ua ntej, kom tsis txhob muaj kev cuam tshuam rau kev siv vim yog txee- lub neej tas sij hawm thiab ua tau raws li qhov xav tau ntawm R&D thiab kev lag luam ntau lawm.
Ua raws li kev thauj mus los thiab kev tswj xyuas tus neeg nqa khoom
Peb xaiv cov neeg nqa khoom nrog GSP daim ntawv pov thawj thiab cov kws kho mob khaub thuas- cov kev tsim nyog hauv kev thauj mus los, thiab txheeb xyuas lawv cov khoom txias- cov ntaub ntawv teev cov khoom siv chains thiab cov ntaub ntawv pov thawj ntawm cov neeg ua haujlwm. Rau kev thauj mus los thoob ntiaj teb, peb hloov mus rau cov kev cai tswj hwm ntawm cov teb chaws uas xav tau ua ntej, ua tiav daim ntawv tshaj tawm kev lis kev cai, cais tawm thiab kev thauj mus los ntawm UN-cov ntaub ntawv ntsig txog kom tsis txhob muaj kev phom sij rau kev thauj khoom, kom ntseeg tau tias kev xa khoom raws li thoob ntiaj teb.
Tag Nrho -Chain Traceability thiab Kev Teb Thaum Muaj Xwm Ceev
Peb tau tsim kom muaj tag nrho -chain traceability system uas suav nrog kev tsim khoom, chaw muag khoom, kev thauj mus los thiab xa khoom, ua rau txhua pawg ntawm Bulk Zavegepant HCl API kom rov qab mus rau nws cov khoom siv raw, kev tsim khoom thiab kev sim cov txheej txheem. Cov phiaj xwm xwm txheej raug tsim los rau qhov txawv txav hauv kev thauj mus los thiab kev cia khoom, tso cai rau cov lus teb sai rau cov teeb meem xws li kev ntim khoom puas tsuaj thiab kev tswj qhov kub thiab txias. Cov khoom yuav raug hloov tam sim ntawd nrog kev sim synchronized kom txo qis kev pheej hmoo rau peb cov neeg siv khoom.
Peb Qhov Zoo
Cov txheej txheem ntau lawm & Standardized Control
Kev tsim cov Zavegepant Hydrochloride tau ua raws li GMP tus qauv. Cov txheej txheem kev sib xyaw ua ke tau raug coj los tswj hwm cov impurities, thiab dual - cov neeg muab ntawv pov thawj tau ua tib zoo xaiv rau kev tswj cov khoom siv raw los xyuas kom meej cov khoom sib xws, uas ua tau raws li qhov yuav tsum tau muaj ntawm R&D, kev sau npe thiab kev lag luam ntau lawm.
Precise Impurity Control & Purity Guarantee
Peb tsom mus rau purity thiab impurity tswj, txais yuav siab -cov cuab yeej xeem precision los ua tag nrho - txheej txheem nrhiav kom tau raws li pharmacopoeial thiab thoob ntiaj teb cov qauv. Cov khoom purity tau lees paub tias muaj ntau dua lossis sib npaug li 99%, thiab cov ntaub ntawv pov thawj COA thiab cov ntawv xeem tau muab rau txhua pawg kom tau raws li qhov yuav tsum tau ua ntawm R & D, kev tshawb fawb soj ntsuam thiab kev sau npe.
Kev Taw Qhia Cia & Kev Kho Kom Zoo
Kev cob qhia kev khaws cia thiab txee- muaj lus pom zoo rau lub neej. Nyob rau hauv lub teeb ntawm cov khoom hygroscopic thiab photosensitive zog, customized lub teeb - pov thawj, ya raws - pov thawj thiab kaw ntim yog saws, nrog tag nrho cov txias - saw saw thiab tiv thaiv shockproof thaum lub sij hawm thauj mus los los xyuas kom meej qhov zoo ntawm cov khoom thaum xa khoom.
Kev Ua Raws Li Kev Tsim Nyog & Kev Pabcuam Kev Nkag Tebchaws Thoob Ntiaj Teb
Peb tuav tag nrho cov kev tsim nyog ua raws cai thiab tuaj yeem muab tag nrho cov ntaub ntawv xav tau rau kev sau npe hauv ntau lub teb chaws, nrog rau tag nrho cov ntaub ntawv qhia. Peb muab 24-teev cov lus teb tom qab muag thiab cov kev daws teeb meem ntawm tus kheej, thiab peb cov khoom raug xa tawm mus rau ntau thaj tsam, tau txais kev lees paub siab los ntawm cov neeg siv khoom thoob ntiaj teb.
Efficient Supply Chain & Fast Delivery Guarantee
Peb tau tsim kom muaj kev paub tab, ruaj khov loj - teev cov txheej txheem tsim khoom thiab lub chaw khaws khoom thoob ntiaj teb los xyuas kom meej tias peb cov khoom siv tseem ceeb Zavegepant HCl API hauv Tshuag, uas ua rau luv luv cov lus teb thiab xa mus. Qhov kawg ua tau zoo heev- rau- qhov kawg ntawm kev ua tau zoo tau muab tso rau hauv qhov chaw kom hloov tau raws li kev txiav txim sai thiab loj - ntim khoom xav tau, ua kom muaj txiaj ntsig zoo ntawm cov neeg siv khoom R&D thiab cov haujlwm tsim khoom. Cia siab rau lub suab thoob ntiaj teb logistics network, peb lav cov khoom xa khoom sai thiab nyab xeeb mus rau qhov chaw thoob ntiaj teb, pab cov neeg siv khoom tuav lub sijhawm ua lag luam.
FAQ
Yog tias koj twb paub txog migraine-cov qauv tsim, siab-Zavegepant HCI API zoo thiab cov kev pabcuam kev pabcuam, thiab txaus siab rau lawv, thov koj xav tiv tauj peb rau kev sib tham. Peb tuaj yeem muab qhov tseeb thiab tiag tiag -cov khoom siv sijhawm, ib qho - ntawm- ib qho kev txhawb nqa, nrog rau cov phiaj xwm kev koom tes los ntawm R&D kev sim mus rau kev lag luam, muab cov khoom siv ruaj khov thiab txhim khu kev qha rau kev nce qib ntawm koj cov haujlwm.
Cim npe nrov: Tuam Tshoj zavegepant hydrochloride manufacturers, lwm tus neeg, Hoobkas
