HK Neopharm Limited yog ib qho ntawm feem txhim khu kev qha manufacturers thiab lwm tus neeg ntawm lenalidomide api nyob rau hauv Suav teb, featured los ntawm cov khoom zoo thiab tus nqi zoo. Thov so assured mus yuav lenalidomide api hauv Tshuag ntawm no thiab tau txais cov lus hais los ntawm peb lub hoobkas. Customized xaj yog txais tos.
Lenalidomide API (CAS 191732-72-6) yog ib qho tseem ceeb thib ob-tiam immunomodulatory antineoplastic API hauv kev soj ntsuam thoob ntiaj teb. Nws muab plaub yam haujlwm tseem ceeb: kev tua cov qog ncaj qha ntawm tes, kev tiv thaiv kab mob, tiv thaiv angiogenesis, thiab tshuaj tiv thaiv rov qab. Nws yog lub hauv paus tseem ceeb raw khoom rau kev kho mob ntawm hematologic malignancies xws li ntau yam myeloma, myelodysplastic syndrome, thiab lymphoma, thiab tseem yog ib qho tseem ceeb synergistic tivthaiv nyob rau hauv kev sib xyaw ua ke rau cov qog nqaij hlav, tuav txoj haujlwm tseem ceeb hauv lub ntiaj teb kev lag luam tshuaj antineoplastic.
Technical Specifications
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Khoom npe |
Lenalidomide API |
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Synonyms |
CAS 191732-72-6, Lenalidomide Powder, Lenalidomide Raw Khoom, Lenalidomide API 191732-72-6 |
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Yam ntxwv |
Tawm -dawb mus rau lub teeb daj crystalline hmoov |
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CAS Nr |
191732-72-6 |
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Assay |
Ntau dua lossis sib npaug li 99.5% (HPLC, Raws li COA) |
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Formula |
C13H13N3O3 |
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Pob |
Pob txheej txheem |
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Cia |
Khaws ntawm -20 degree |
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Qauv |
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Lenalidomide API ua los ntawm cov txheej txheem tseem ceeb ntawm cov kua nplaum molecular. Nws tshwj xeeb khi rau Cereblon (CRBN) E3 ubiquitin ligase complex, precisely degrades oncogenic transcription yam xws li Ikaros thiab Aiolos, blocks qog cell proliferation signals, thiab induces apoptosis. Lub caij no, nws ua rau T-cell thiab NK-cell kev ua, txhim kho kev tiv thaiv kab mob, inhibits qog angiogenesis, thiab thaiv cov qog nqaij hlav los ntawm ntau txoj hauv kev. Cov ntaub ntawv pov thawj lees paub tias Lenalidomide Powder ua ke nrog dexamethasone rau relapsed thiab refractory ntau myeloma ua tiav lub hom phiaj teb tus nqi ntawm 60.6%. Kev muaj sia nyob nruab nrab tsis pub muaj sia nyob txuas ntxiv mus rau 13.9 lub hlis, thiab tag nrho cov ciaj sia nyob ntev tshaj li 3 xyoos, uas yog qhov zoo tshaj plaws rau kev siv tshuaj khomob. Nws cov neurotoxicity qis dua li thalidomide, ua rau nws muaj kev nyab xeeb rau kev kho mob mus sij hawm ntev.
Khoom nta
Lenalidomide Raw Khoom yog cov dawb-dawb rau lub teeb daj crystalline hmoov. Nws yog odorless, iab hauv saj nrog cov qauv siv lead ua, featuring zoo heev flowability. Raws li lub zog muaj zog antineoplastic API, peb cov khoom muaj cov ntsiab lus tseem ceeb Ntau dua lossis sib npaug li 99%, nrog rau qhov siab tshaj plaws ib qho impurity Tsawg dua lossis sib npaug rau 0.10%. Cov ntsiab lus tseem ceeb suav nrog cov kuab tshuaj seem, cov hlau hnyav (Pb, As, Cd, Hg, thiab lwm yam), cov khoom tsis huv, cov kab mob endotoxins, thiab microbial txwv tag nrho dhau qhov kev xav tau thoob ntiaj teb. Peb cov tuam txhab koom tes txais cov txheej txheem ntsuab synthesis, tshem tawm cov tshuaj lom halogenated reagents. Los ntawm ib lub lauj kaub catalytic coupling thiab cov cuab yeej siv hluav taws xob txo qis, tag nrho cov txiaj ntsig tau nce mus rau saum 75%, ua tau raws li cov qauv thoob ntiaj teb rau kev tsim tshuaj.
Lenalidomide API yog lub hom phiaj siab thiab ua haujlwm sai. Tom qab kev tswj hwm qhov ncauj, qhov siab tshaj plaws plasma concentration tau mus txog hauv 0.5-1.5 teev, nrog rau ib nrab hnub ntawm 3 teev. Kev noj ib zaug ib hnub ua kom muaj txiaj ntsig zoo ntawm cov ntshav plasma. Nyob rau hauv cov nqe lus ntawm immunomodulation thiab reversal tsis kam, Lenalidomide API txo cov pro-inflammatory yam xws li TNF- thiab IL-6, txhim khu lub cev tiv thaiv kab mob cytotoxicity. Thaum ua ke nrog cov kws khomob, cov neeg saib xyuas, lossis cov tshuaj tiv thaiv kab mob tiv thaiv kab mob, nws thim rov qab cov qog ua haujlwm los ntawm 4-8 folds, txhim kho cov tshuaj khomob ntau dua 30%, thiab txo qis plawv, plab hnyuv, thiab lwm yam tshuaj lom neeg muaj feem cuam tshuam. Lenalidomide API qhia tias tsis muaj nephrotoxicity lossis hepatotoxicity. Qib 3/4 hematologic tsis zoo tshwm sim yog tswj tau thiab sai sai los ntawm kev hloov koob tshuaj. Nws tsis ua rau alopecia lossis ntuav hnyav heev ntawm cov tshuaj khomob ib txwm siv, ua rau cov neeg mob siab ntev thiab tsim nyog rau kev siv mus ntev rau cov neeg laus thiab cov neeg mob qog noj ntshav.
Full-Cycle Quality Control thiab Stable Quality
Full-Process Traceability Control
Peb koom tes nrog cov koom tes ua lag luam uas muaj ntawv pov thawj los siv tag nrho-chain kaw-loop tswj rau Lenalidomide API 191732-72-6 los ntawm cov khoom pib mus rau cov khoom tiav. Cov ntaub ntawv pib yog los ntawm cov neeg muag khoom tsim nyog, nrog COA suav nrog rau txhua pawg. Cov txheej txheem suav nrog kev sib txuas, kev ua kom huv, ziab, milling, thiab ntim khoom tau ua tiav hauv GMP chav huv nrog cov txheej txheem sijhawm teev tseg. Txhua batch yog muab ib tug tshwj xeeb batch naj npawb, nrog tag nrho khaws cia ntawm cov ntaub ntawv xeem, ua kom tag nrho traceability, verifiability, thiab rov kuaj dua thoob plaws hauv kev tsim khoom, tshuaj xyuas, cia, thiab kev thauj mus los. Txhua qhov kev xa khoom ntawm Lenalidomide Raw Material yog nrog rau daim ntawv pov thawj kev soj ntsuam tag nrho suav nrog cov ntsiab lus, cov khoom muaj feem xyuam, noo noo, residue ntawm ignition, hnyav hlau, residual solvents, microbial txwv, siv lead ua daim ntawv txheeb xyuas, thiab lwm yam khoom, nrog cov ntaub ntawv tseeb thiab pov thawj los txhawb kev sau npe hauv tsev thiab thoob ntiaj teb.
Strict Standard thiab Compliance Assurance
Lenalidomide API nruj me ntsis raws li ICH Q7, USP, EP, JP, thiab CP pharmacopeial cov qauv, ua cov kev ntsuam xyuas tag nrho nrog rau HPLC assay, GC residual solvent analysis, ICP-MS elemental impurity analysis, XRD crystal form identification, thiab microbial limit testing. Cov ntsiab lus tseem ceeb tshaj li cov qauv tshuaj kho mob thoob ntiaj teb. Cov khoom lag luam muaj qhov ua tiav kev sau npe thoob ntiaj teb, muab cov ntaub ntawv tag nrho suav nrog DMF cov ntaub ntawv, pob khoom siv, cov ntaub ntawv ruaj khov, thiab cov ntaub ntawv ntsuam xyuas genotoxic impurity. Qhov no txhawb cov neeg siv khoom hauv kev ua tiav kev tshuaj xyuas los ntawm cov cai tswj hwm hauv Tebchaws Europe, Tebchaws Meskas, Nyiv, Kaus Lim Qab Teb, Qab Teb Asia, Middle East, thiab lwm thaj chaw, ua kom muaj txiaj ntsig kev lag luam ntawm cov qauv tiav.
Nruam Qhov System Optimization
Kev txhawb nqa los ntawm kev hloov kho thev naus laus zis tsis tu ncua ntawm cov koom tes koom tes, peb txuas ntxiv txhim kho cov txheej txheem sib xyaw thiab kev ua kom huv ntawm Lenalidomide Powder los txhim kho purity, stability, ntau lawm efficiency, thiab nqi-zoo. Lub cev muaj zog ntawm kev sib txawv ntawm kev tuav, kev hloov pauv, thiab kev tshuaj xyuas txhua xyoo yog tsim, nrog rau kev ntsuas thiab kev hloov kho kom zoo ib yam thiab ruaj khov zoo hauv txhua pawg ntawm Lenalidomide API, muab cov neeg siv khoom nrog cov khoom siv raw khoom siv ntev ntev.
Daim ntawv thov Scenario
Hematological Malignancies
Lenalidomide API yog cov khoom siv tseem ceeb rau thawj kab, kab thib ob, thiab kev kho mob ntawm ntau yam myeloma. Kev sib xyaw ua ke nrog dexamethasone yog cov txheej txheem rau kev rov ua dua thiab rov ua dua ntau yam myeloma; Nws kuj yog siv rau kev saib xyuas tom qab autologous qia cell transplantation, txuas ntxiv kev vam meej tsis muaj sia nyob los ntawm ntau tshaj ob zaug thiab txo qis kev pheej hmoo rov tshwm sim. Tsis tas li ntawd, Lenalidomide API yog qhia rau mantle cell lymphoma, follicular lymphoma, thiab non-germinal center diffuse loj B-cell lymphoma. Ua ke nrog rituximab hauv R2 kev tswj hwm, 3-xyoo kev vam meej-dawb txoj sia nyob tau nce mus txog 77%, nrog rau cov tshuaj tiv thaiv qis dua li kev siv tshuaj khomob, muab kev nyab xeeb rau cov neeg mob qog noj ntshav.
Solid Tumor Adjuvant Therapy
Cov khoom lag luam modulates cov khoom qog microenvironment thiab txhim kho qog perfusion. Thaum ua ke nrog cisplatin, paclitaxel, anthracyclines, lossis PD-1 / PD-L1 inhibitors, nws ua rau cov qog inhibition ntau dua 40% thiab thim rov qab cov tshuaj tiv thaiv ntau. Nws yog tsim rau rhiab heev thiab toxicity txo nyob rau hauv cov qog nqaij hlav nrog rau lub ntsws, daim siab, lub mis, thiab cov qog nqaij hlav hauv plab, uas yog qhov tsim nyog rau kev nthuav dav daim ntawv thov ntawm kev sib xyaw antineoplastic regimens.
Innovative Drug R & D thiab Standard Reference
Lenalidomide Powder tuaj yeem siv los ua tus qauv siv thiab ua haujlwm rau kev tshawb fawb tshuaj thiab tshuaj toxicological, kev sim tshuaj pharmacokinetic, kev tshuaj ntsuam xyuas, thiab kev tsim qauv zoo. Nws kuj txhawb R & D ntawm Lenalidomide derivatives, prodrugs, nanoparticles, qhov ncauj sustained-tso npaj, thiab lwm yam tshuaj tshiab, ua kom yooj yim breakthroughs nyob rau hauv oncology R&D thiab ua tau raws li cov kev xav tau ntawm cov tsev kawm ntawv, cov chaw tshawb fawb, thiab cov tuam txhab tshuaj.
Ntim thiab thauj
Lenalidomide Powder yog lub tshuab nqus tsev ntim rau hauv cov tshuaj-qib aluminium foil hnab nrog cov khoom siv thiab kev tiv thaiv lub teeb, nyob hauv cov drums fiber ntau los yog yas nruas. Lub ntim muab lub teeb ua haujlwm, tiv thaiv ya raws, tiv thaiv oxidation, thiab lub cev muaj zog kom ruaj khov zoo thaum khaws cia thiab xa khoom. Standard ntim: 1 kg, 5 kg, 10 kg, 25 kg. Customized ntim kuj muaj nrog adjustable specifications thiab cov ntaub ntawv raws li kev thov. Logistics nruj me ntsis raws li cov qauv tshuaj thiab cov khoom txaus ntshai kev thauj mus los nrog rau qhov kub thiab txias thiab tiv thaiv kev thauj mus los thoob plaws. Kev faib tawm hauv tsev yog tswj hwm los ntawm pab pawg kws tshuaj logistics; Kev thauj mus los thoob ntiaj teb ua raws li UN cov cai, muab kev thauj khoom huab cua, hiav txwv freight, thiab kev nthuav qhia thoob ntiaj teb nrog kev taug qab thiab taug qab kom nyab xeeb thiab xa khoom raws sijhawm. Peb muaj tag nrho cov kev tsim nyog export, cov ntaub ntawv kev lis kev cai, thiab freight forwarding kev pab cuam kom ua tau zoo thiab raws li kev lis kev cai clearance rau ntiaj teb no cov neeg muas zaub.
Peb Qhov Zoo
Stable Capacity thiab In-Stock Supply
Peb muaj daim ntawv cog lus mus sij hawm ntev nrog ntau yam GMP, FDA, thiab CEP tau lees paub cov koom haum koom tes, ua kom cov lus teb ceev ceev thiab xaj ntau. Peb txhawb R & D pilot sim thiab loj-ntim khoom, nrog rau cov ntawv cog lus mus sij hawm ntev los xyuas kom meej cov saw hlau ruaj khov.
High-Standard Quality Assurance
Cov khoom tsim tawm los ntawm cov chaw tsim khoom muaj ntawv pov thawj nrog kev soj ntsuam nruj nruj. Lenalidomide API purity yog ruaj khov ntau dua lossis sib npaug li 99.0%. Kev pheej hmoo suav nrog genotoxicity thiab cov hlau hnyav yog tswj nruj, muab kev ruaj ntseg tseem ceeb rau kev tsim qauv kev nyab xeeb thiab R & D ua tiav thiab pab cov neeg siv khoom tsim cov khoom zoo antineoplastic.
Mature Export thiab Kev Pabcuam Ntiaj Teb
Nrog ntau tshaj 10 xyoo ntawm kev xa tawm thoob ntiaj teb thiab kev ua tiav ntawm kev lis kev cai tshaj tawm, tshuaj xyuas, kev xa khoom, thiab cov ntaub ntawv, peb tuaj yeem muab Lenalidomide API (CAS 191732-72-6) rau ntau tshaj 100 lub teb chaws thiab cheeb tsam suav nrog Europe, Tebchaws Meskas, Nyiv, Kaus Lim Qab Teb, Qab Teb Asia, Middle East, thiab South America. Peb kuj muab kev txhawb nqa ntau hom lus uas ua kom ruaj khov ntxiv, .
Customization thiab Technical Support
Peb muab cov kev pabcuam customized suav nrog qhov hloov pauv qhov loj me, txoj kev ziab, thiab ntim cov specifications. Peb pab cov neeg siv khoom daws teeb meem kev sib tw hauv kev tsim R & D, ntau lawm, thiab sau npe.
Comprehensive After-Sales System
Peb tau tsim 7 × 12 teev cov lus teb sai sai tom qab kev muag khoom kom sai li sai tau raws li kev txiav txim, kev xa khoom, kev ua haujlwm zoo, thiab cov teeb meem kev lag luam, ua kom muaj kev txhawj xeeb tsis muaj kev txhawj xeeb los ntawm kev nug, kev yuav khoom, thiab daim ntawv txais nyiaj siv, muab cov neeg siv khoom nrog ib qho kev pabcuam kev yuav khoom.
FAQ
Cim npe nrov: Tuam Tshoj lenalidomide API manufacturers, lwm tus neeg, Hoobkas
